Choose xylene or Clear-Rite 3 clearing reagents for lipid extraction, optimal paraffin infiltration and excellent deparaffinization and clearing during staining. Xylene is a para-depleted reagent that reduces processing artifacts; it contains a low concentration of benzene. Clear-Rite 3 reagent is an isoparaffinic-based xylene substitute that renders tissue less brittle, even after extended exposure. It is a universal clearing agent that can be used in all tissue processors and automatic stainers.